Combined InCl3- and amine-catalyzed intramolecular addition of alpha-disubstituted aldehydes onto unactivated alkynes.
Identifieur interne : 001A75 ( Main/Exploration ); précédent : 001A74; suivant : 001A76Combined InCl3- and amine-catalyzed intramolecular addition of alpha-disubstituted aldehydes onto unactivated alkynes.
Auteurs : RBID : pubmed:20462188Abstract
The combination of enamine-type catalysis to the indium-catalyzed activation of alkynes allows the efficient preparation of functionalized cyclopentanes bearing a quaternary stereogenic center. A broad range of formylalkynyl derivatives has been prepared. The InCl(3)/(Cy)(i-Pr)NH system efficiently promotes the carbocyclization reaction of alpha-disubstituted aldehydes in good to excellent yields.
DOI: 10.1021/ol100729t
PubMed: 20462188
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